Blar i forfatter "Kool, Jaap"

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    • CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication 

      van der Wal, Yorick Andreas; Nordli, Henriette R.; Akandwanaho, Allan; Greiner-Tollersrud, Linn; Kool, Jaap; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Background: Interferon (IFN) responses are critical in the resolution of viral infections and are actively targeted by many viruses. They also play a role in inducing protective responses after vaccination and have been successfully tested as vaccine adjuvants. IFN responses are well conserved and function very similar in teleosts and mammals. Like in mammals, IFN responses in piscine cells are ...

    • The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection 

      van der Wal, Yorick Andreas; Jenberie, Shiferaw; Nordli, Henriette; Greiner-Tollersrud, Linn; Kool, Jaap; Jensen, Ingvill; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)
      The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response ...